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This is mechanistically different from GLP-1 receptor agonists like semaglutide or tirzepatide, which are large peptide chains stabilised by complex tertiary structures that degrade slowly even at suboptimal temperatures

The inefficient recycling of Se in BAT for the synthesis of selenoproteins, particularly GPX1 and GPX4 which are involved in adaptive thermogenesis, may potentially lead to increased oxidative stress within this tissue, yet is insufficient to curb heat production

This inquiry is not just about whether its safe

Dong S, Xu J, Jia T, Xu M, Zhong C, Yang G, et al

Tumour heterogeneity and the ability of tumour cells to rapidly mutate and develop evasion strategies makes the development of non-invasive imaging capabilities to interrogate these hallmarks as biomarkers and monitor them longitudinally and quantitatively particularly important