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With the deepening research on the pathogenesis of PCOS and its chronic inflammatory state, it has been found that a variety of signaling pathways are involved in the initiation and progression of inflammation (222), among which the more important ones such as PI3K/AKT, MAPK, and AMPK signaling pathways, and the SCFAs have anti-inflammatory roles in PCOS, but these signaling pathways have been reported less frequently in the study of SCFAs

Peak picking was conducted by identifying local maxima with a slope threshold of 100, determined based on the peak shape

Plasminogen-related growth factors

The generated ROS, in turn, induces mitochondrial DNA damage, contributing to oxidative stress (42, 48)

Kim JM, Choi YM, Jung SA, Yang HR