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Wnt/-catenin pathway forms a negative feedback loop during TGF-1 induced human normal skin fibroblast-to-myofibroblast transition

Like other type I proteins that traverse the lipid bilayer, the lipid-spanning portion of the peptide would be predicted to adopt an alpha-helical secondary conformation, a secondary structure characterized by every amino acid interacting with the 4th amino acid beyond, the so-called i + 4 rule of alpha-helical protein conformations