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In AD, A accumulation within neurons increases mitochondrial ROS production and sensitizes mitochondria to apoptosis by promoting BAX activation [80]

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Limitations It is important to note that the terminology describing monthly or every-2-months injection intervals (used in the AL label) and every-4-weeks or every-8-weeks injection intervals (used in AL clinical trial study designs) can vary depending on context, but these injection intervals are generally considered equivalent, covering similar time periods in clinical use.Reference Lertxundi, Hernandez and Medrano 23 A small degree of variability in AL injection timing (ie, injection intervals of monthly vs every 4 weeks or every 2 months vs every 8 weeks) would not have a clinically significant impact on plasma aripiprazole concentrations over the injection interval.Reference Hard, Mills, Sadler, Turncliff and Citrome 17 The AL dosing regimens are characterized in this article as upper, lower, or intermediate regimens based on the expected steady-state plasma aripiprazole concentrations associated with each