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It has been reported that buthionine sulfoximine (BSO), a GSH synthesis inhibitor, treatment induced or worsened radiation-related disease and health risk in mice, such as cataracts 16 , brain inflammation 10 , hypertension 17 , atherosclerosis 18 , decreased HDL levels 19 , increased oxidative DNA damage 20 , and tumorigenesis 21

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During tumor progression, macrophage-derived TGF-1 can inhibit transcription through SMAD signaling, thereby promoting ferroptosis (85) and thus representing a complex interplay between immunosuppressive cytokines and ferroptotic mechanisms

[DOI] [PubMed] [Google Scholar] 1152.Shears LL, 2nd, Kibbe MR, Murdock AD, Billiar TR, Lizonova A, Kovesdi I, Watkins SC, Tzeng E

Vogt NM, Romano KA, Darst BF, Engelman CD, Johnson SC, Carlsson CM, et al