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PMID: 44 CainJHurrellBAkbariO

Key active ingredients included emodin, aloe-emodin, and physcion, which target the NOS2 and NOS3 enzymes

Another class of gastric acid inhibitors known as histamine 2 (H 2 )-receptor antagonists (e.g., cimetidine, famotidine, and ranitidine), often used to treat peptic ulcer disease, has also been found to decrease the absorption of vitamin B 12 from food

Doulias PT, Greene JL, Greco TM, Tenopoulou M, Seeholzer SH, Dunbrack RL, et al

Similarly, replacing the 2-chloroacetamide with a 3-chloroacetamide derivative such as in cluster-4 also proved unfavourable and resulted in loss of potency