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Lipoedema management: Gaps in our knowledge

Priorities for research include head-to-head evaluation of analogs in EMS models with integrated pharmacokineticpharmacodynamic mapping and iterative chemistry to lower promiscuous binding without compromising on-lesion potency

10.1080/2162402X.2017.1316437 249 SerZ.GaoX.JohnsonC.MehrmohamadiM.LiuX.LiS.et al

It has been found that the ferroptosis inducer, erastin, irreversibly activates CHOP/PUMA within the p53 signaling pathway, thereby enhancing the sensitivity of tumor cells to apoptosis inducers and facilitating apoptosis (Hong et al., 2017)