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PLoS One 7:441448 Moncada S, Palmer RM, Higgs EA (1991) Nitric oxide: physiology, pathophysiology, and pharmacology

The substances under review are among those that former president Joe Biden's administration restricted from compounding, notably over a lack of human clinical trial data

Epub 2010 Jun 5

doi: 10.1097/tp.0000000000004668 105

One new hypothesis is that mitochondrial ROS generated during hypoxia promote the oxidation of cysteine residues within PHD2 resulting in oxidative PHD2 homodimerization and inactivation, leading to HIF- protein stabilization 26