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Gondin J, et al

Diacylglycerol levels are elevated in many models of insulin resistance [28] and directly activate protein kinase C [2932]

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Together, our data reveal correlations between different cell types and ferroptosis at the single-cell level, and identify factors that may affect the sensitivity of dopaminergic neurons to ferroptosis

Therefore, lactate absolutely has the ability to activate the GPR81 in the physiological state (human blood lactate concentration range is 0.52 mM) (193)