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Andrews PA, Murphy MP and Howell SB

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Inflammation involves the innate immune response, where mTOR can regulate the function of mast cells, phagocytes and natural killer cells 29

The phase 2 trial showed 22.8% average weight loss at 48 weeks with the 8mg dose, only 1.4 percentage points less than the 12mg dose

For instance, IL-17A has been reported to be present in Hidradenitis suppurativa , a devastating neutrophil-rich inflammation with formation of nodules and abscesses (30)