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Oxidative stress response and nrf2 signaling in aging

doi: 10.1021/acsomega.0c00804 65 LinRPiaoMSongY

Swiegers et al., 2007

Footnotes CONFLICTS OF INTEREST The authors declare no potential conflicts of interest

For instance, overexpression of prostacyclin synthase or inhibition of miRNA-34a has been demonstrated to shift macrophage populations towards an M2 phenotype, reducing inflammation and enhancing tissue repair in experimental models of ALD.34 41 These findings highlight the therapeutic potential of targeting macrophage polarisation to balance pro-inflammatory and anti-inflammatory responses, offering a strategy to mitigate the liver damage caused by chronic alcohol consumption