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In particular, it promotes intestinal integrity by activating the transcription of the TJ protein claudin-1

Once in the central nervous system, they act as potent neuroprotectants by inhibiting microglial over-activation, mitigating neuroinflammation via the TLR4/NF-B and NLRP3 pyroptosis pathways, and simultaneously upregulating tight junction proteins (e.g., Claudin-5, ZO-1) to restore or even enhance BBB integrity (Yue et al., 2021

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