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Diffraction data were collected at the Pohang Accelerator Laboratory (PAL, beamline BL-7A) and were processed and scaled using the HKL-2000 package 31 (Table S2)

OS plays an important role in chronic, inflammatory pathologies (Kehrer and Klotz, 2015), progressive brain damage and the pathogenesis of neurodegenerative diseases such as: Amyotrophic lateral sclerosis (ALS), Alzheimers disease (AD), Parkinsons disease (PD), Multiple sclerosis (MS), Huntingtons disease (HD), and Spinocerebellar ataxia (SA) (Dias et al., 2013

The Ethics Committee of the Sechenov Institute of Evolutionary Physiology and Biochemistry RAS (Study No

Mitochondria are the metabolic centers of most mammalian cells, and are important sources of ROS

For glutamine starvation assays, cells were seeded in the same manner as described above in normal media