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While it is unsurprising that many ALS symptoms are related to signs of copper deficiency, resulting in vascular, antioxidant system and mitochondrial oxidative respiration deficiencies, there are also signs of copper toxicity such as ROS generation and enhanced protein aggregation

66 A previous study utilized peptide amphiphile nanofibers functionalized with chemical groups from native GAG molecules, such as sulfonate, carboxylate, and hydroxyl, to induce chondrogenic differentiation in rat MSCs

Moreover, overly high NO production in the brain can form peroxynitrite , a potent oxidant that damages neurons and has been implicated in neurodegenerative diseases

This is why MOTS-c isn't available as a capsule or powder in any form that would be meaningfully bioavailable

The following peptides were affected by the FDA ban