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That distinction matters more than it might seem at first glance

Nature 222 : 385386

however, when produced imbalanced, they can cause oxidative stress that damages cellular structures like lipids, proteins, and DNA

Fan X, Dong T, Yan K, et al

IC-MS of the polar extracts revealed no significant differences between 2D- and 3D-cultured cells in the abundance or isotopological distribution of the glycolytic intermediates G6P, F6P, and pyruvate (Fig