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A recent meta-analysis of 21 randomized controlled trials on the effect of folic acid supplementation on endothelial function suggests that this intervention significantly improves flow-mediated dilation percentage (FMD%) and flow-mediated dilation, but not end-diastolic diameter (EDD) or intracellular adhesion molecule 1 (ICAM-1) expression (Zamani et al., 2023)

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Type 2 cytokines are inducers of ALOX15 expression [92], which in turn supports the release of chemokines to recruit activated T cells in lung epithelial cells in vitro [93]

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This indicates that innate cytokine signaling directly amplifies the CD8 + T cell pool

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