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The analog, derivative or variant peptides may contain chemical modifications, eg, chemical modifications intended to improve metabolic stability, including further chemical manipulation after synthesis of the main peptide chain

Reitmaier, S., Wolfram, U., Ignatius, A., Wilke, H

This enhances brain-derived neurotrophic factor (BDNF) expression by 25-30%, promoting hippocampal neuron growth, as evidenced by fMRI studies showing 15-20% improved memory recall on the Rey Auditory Verbal Learning Test (RAVLT) over 2 years