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Preclinical investigational data associate Vesilute with chromatin decondensation through interaction with AT-rich ATTT DNA motifs, proposed downstream reactivation of transcriptionally silenced genes in aged cellular models, glycogen aggregation inhibition in detrusor smooth muscle cells, calcium signaling attenuation in urinary bladder tissue, and modulation of pro-inflammatory cytokine expression patterns, including IL-6 and TNF-alpha pathways in controlled in vitro research settings

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Amersham, GE Healthcare, Buckinghamshire, UK) was studied in Franz-type diffusion cells as described previously 46