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MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA- c) is a small peptide comprised of 16 amino acids, which is encoded by DNA not in the nucleus, but inside the mitochondrial genome, specifically inside the gene that encodes the mitochondrial 12S ribosomal RNA

A., Steinhilber, D., Sgambato, A., & Patrignani, P

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These findings were confirmed by the analysis of the Delocalization Indices (D.I., Fig.2), which measure the average number of electron pairs delocalized (shared) between two atoms