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Construction of chimeric receptors between human (h) and mouse (m) and their functional analysis demonstrated that the TMD of TAS1R1 is the key domain for switching the PAM/NAM activities of methional

It also modulated nuclear factor kappa B (NF-B) and transforming growth factor-beta (TGF-) signaling and reduced collagen type I (Col-I) and collagen type III (Col-III), connective tissue growth factor (CTGF), and neutrophil elastase (NE)

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