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Pro-xylane (30% in water) is the catalytic substrate of the recombinant carbonyl reductase R129E/D210F, whose key activity lies in the high stereoselectivity of the -S configuration

Interestingly, Pseudomonas nitroreducens GGT (PnGGT) exhibits higher hydrolytic activity than transpeptidase activity despite high sequence similarity with EcGGT (Imaoka et al., 2010)

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This compound has the advantage of being specific for the TRPM2 member of the TRP channels, although targeting other molecules, such as JAK2 [103]

Therefore, we could not identify the impact of a single innate immune pathway involved in tumor regression induced by BCG immunotherapy, but these pathways could be acting in a coordinated manner to control melanoma in response to BCG