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Nature 582 , 571576 (2020)

No preparation instructions, dosing guidance, application guidance, or therapeutic claims are provided

Oxidative stress, which occurs when cellular defense systems fail to counterbalance the generation of free radicals, has been recognized as a major contributor to impaired cell growth, reduced productivity and increased protein microheterogeneity 38,44,45

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Therefore, dysfunction of GPX4 leads to increased ferroptosis, while iron deficiency or failure of related antioxidant systems can exacerbate this process ( Figure 1 )