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NAC has been used as a component of supplement and expansion medium for the treatment of cells, but at higher concentration NAC decreases cell viability [22]Mitsopoulos P, Suntres ZE

PLoS One 5 : e15367

The observed ocular abnormalities always cosegregated with the VEGFA hyper allele (VEGFA lacZ/WT ) and were not observed in any of the examined control littermate VEGFA WT/WT mice, making it highly unlikely that another mutation may have contributed to the observed ocular abnormalities in VEGFA hyper mice

9.4 Ferroptosis and necroptosis Ferroptosis and necroptosis can be triggered by the common stimulatory factor ROS and jointly participate in the process of oxidative stress-induced cell death (169)

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