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Absolute amounts and status of Nrf2-Keap1-Cul3 complex within cells

Melatonin functions in scavenging free radicals might be classified in to four main categories ( Figure1) : (1) as an antioxidant directly scavenges ROS [31], (2) stimulates the antioxidant enzymes production and activation [32,33] and (3) increases the efficacy of mitochondrial functions by improving MPTP, inhibition of cytochrome c release and refining of oxidative phosphorylation in mitochondrial respiratory chain which further will decrease the peroxidation of membrane lipids [34]

However, immunization procedures may be undertaken in patients who are receiving corticosteroids as replacement therapy, e.g., for Addisons disease