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He noted, Sleep and watchfulness, both of them, when immoderate, constitute disease. He equally recognized the value of nutrition, as he also said, Let food be thy medicine and medicine be thy food. And so the deep roots of medicine established the vital nature of nutrition and sleep to well-being, and now emerging science shows how they are interrelated

Moreover, Ser and Thr sites for GlcNAcylation and phosphorylation co-exist in the same protein and these modifications often share the same sites, establishing a complex functional relationship (Wang et al., 2007

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