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Current research on natural products continuously reveals new bioactive compounds that may manage developing health issues, rendering them essential in the ongoing search for innovative therapies [67,68,69,70]

This upregulation extends to key antioxidant systems, including glutathione (GSH) and thioredoxin (TRX), which help maintain redox balance and support tumor survival [35]

All authors read and agreed with the manuscript submission

The same lack of increased basal oxidative stress was recapitulated with shRNA depletion of ATM (Fig

Along with this damage, there is a reduction in mitophagy, the process of removing damaged mitochondria, leading to accumulation of damaged mitochondria further contributing to systemic inflammation