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Zeng B, Ge C, Li R, Zhang Z, Fu Q, Li Z, et al

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& Zhang, Y

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The action of estradiol is primarily directed by interaction with the estrogen receptor (ER) nuclear receptors (alpha and beta) in peripheral target tissues further modulated via feedback by GH and IGF-1 (Veldhuis et al., 2006)

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This supports the notion that histone modifications can serve as a main cellular platform for signal integration

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