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Sopko et al reviewed the physiological and pathological mechanisms of the RhoA/ROCK pathway in penile vascular endothelial dysfunction and summarized the possible treatment directions [186]

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In a randomized, double-blind, placebo-controlled trial, daily supplementation with Lactobacillus plantarum ECGC 13110402 for 12 weeks in adults with moderate hypercholesterolemia resulted in a significant reduction in LDL cholesterol and hs-CRP compared to placebo, suggesting a direct benefit of probiotics on cardiovascular risk markers in humans (Costabile et al., 2017)