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Various factors have the potential to impede BBB function and compromise BBB integrity by influencing microglial activity (38, 39)

Catalase (CAT) , a heme enzyme that catalyzes the decomposition of H 2 O 2 to water + molecular O 2 , provides a vital cellular antioxidant defense 570

IR contributes to reductions in body weight and muscle strength, as it not only enhances lipolysis and the release of free fatty acids but also suppresses the GH/IGF-1 axis and increases myostatin levels in muscle, ultimately inhibiting skeletal muscle protein synthesis [220]

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The reconstitution math and per-IU equivalences in this article describe physical concentrations in a vial, not human therapeutic doses