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10.1111/anu.12403 [DOI] [PMC free article] [PubMed] [Google Scholar] Thieme R., Kurz S., Kolb M., Debebe T., Holtze S., Morhart M., et al

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Lysine lactylation in diseases: beyond histone lactylation

Conclusion: In the DDC acute cholangiopathy model, FXR agonists are protective through STAT3 signaling, M1 to M2 macrophage polarization, and by inducing fatty acid oxidation, suggesting STAT3 as a potential therapeutic target in PSC

Deep learning (DL) architectures developed based on deep artificial neural networks have shown the ability to process big data with little human intervention and have been applied to the chemical and bioinformatics fields, which may be adopted in DILI predictions (Xu et al., 2015)