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The glyoxalase I and II which are responsible for catalyzing the conversion of methylglyoxal (a by-product in glycolysis) to lactic acid are among these enzymes [76]

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3134 However, most of the previously reported MnO 2 -based nanozyme systems only have single or dual therapeutic modes, and their therapeutic effects are often limited by insufficient enhancement of oxidative stress and the lack of a synergistic mode for further enhancing and maintaining oxidative damage

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