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The metabolomics data have been deposited to the EMBL-EBI MetaboLights database with the identifier MTBLS14139

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Interestingly, in South America (Argentina and Venezuela), possession of the HLA DRB1*1301 allele, which does not conform to the shared motif model mentioned above, harbouring the sequence LIEDER at positions 6772 [44, 45, 57], not only does predispose to pediatric AIH-1 but is also associated with persistent infection with the endemic hepatitis A virus [43, 58]

In addition to the described events at the cellular level, aging also promotes the dysfunction of the pineal gland, which is, as mentioned, an important source of melatonin, thus affecting several physiological processes mainly related to circadian rhythms

SLC39A11 (ZIP11), the sole member of the GufA subfamily of SLC39A/ZIP proteins (Fig