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BCG (Pasteur strain) used for vaccination was prepared in-house in 7H9 broth supplemented with 10% ADC enrichment medium and 0.05% Tween 80 (Becton Dickinson, UK)

Hu D, Eftink MR (1993) Interaction of indoleacrylic acid with Trp aporepressor from Escherichia coli

However, further dose-response analysis and adjustment for intake of other vitamin and mineral supplements indicated that all-cause mortality risk was significantly increased by 7% only at a dose of 2,000 IU/day, which is notably higher than the UL for adults (1,100 IU/day of synthetic tocopherol or 1,500 IU/day of natural tocopherol)

Nausea represents the most frequently reported adverse reaction, affecting a significant proportion of patients, particularly during the initial weeks of therapy or following dose increases

This means its already in a form that the body can use , without needing to convert it first