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Srivatsan R, Das S, Gadde R, Manoj-Kumar K, Taduri S, Rao N, et al

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Treatment of this condition requires a careful evaluation of the patients history and symptoms, examination of the pelvis and anus, and specialized testing (see section on Anal Incontinence )

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Recent meta-analysis indicates that the majority of studies (9 out of 11) report no significant circadian variation in total protein content while the few studies that do report variation may reflect false positive findings due to acrophase mismatch [3]