glutathione breaks disulfide bonds

glutathione breaks disulfide bonds Reaction formulas of bond reduced by a) GSH or b) DTT. c) File:Disulfide Bond Formation.jpg - Wikipedia

Name: glutathione breaks disulfide bonds Reaction formulas of bond reduced by a) GSH or b) DTT. c) File:Disulfide Bond Formation.jpg - Wikipedia
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File:Disulfide Bond Formation.jpg Wikipedia Oxidant induced glutathionylation at protein disulfide bonds ScienceDirect Mechanistic insights on the reduction of glutathione disulfide by protein disulfide isomerase PNAS Breaking a Couple: Disulfide Reducing Agents Mthembu 2020 ChemBioChem Wiley Online Library The role of glutathione in disulphide bond formation and endoplasmic reticulum generated oxidative stress PMC

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Description

This process generates reactive byproducts that require glutathione for detoxification

The DNA sequence spanning the CBS gene ARE motif located 4970 bp upstream of the transcript start site and its mutants were cloned into a GFP expressing reporter pEGFP-N1 (PT3054, Clontech) with sequence specific primers (Supplementary Table 1)