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Dosing & Reconstitution Guide Educational guide for reconstitution and intermittent dosing Standard Protocol (2 mL = 2,500 IU/mL) Frequency: Inject 3 times weekly subcutaneously (e.g., Monday/Wednesday/Friday)

accepted September 20 th , 2011

CagriSema Dosing# CagriSema is a fixed-ratio combination in a single pen injector: Once-weekly subcutaneous injection containing both cagrilintide and semaglutide REDEFINE 1: Dose escalation to the maintenance combination dose over several weeks Dosing ratio: Fixed ratio optimized during the phase 2 program Dosing Comparison Table# Side Effects Comparison# Amycretin Side Effects# In the phase 1b/2a trial published in The Lancet, once-weekly subcutaneous amycretin up to 60 mg had a safety and tolerability profile consistent with GLP-1 and amylin agonists

The mobile phase A consisted of 40% water, 60% acetonitrile, and 10 mmol/L ammonium formate

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