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Materials and methods Animals and experimental design Nine-week-old male Fischer 344 rats (Charles River Laboratory, Japan), weighing from 180-200 g, were maintained at 23C, given standard laboratory chow and water ad libitum, and kept under a 12 h light (7:00-19:00)/12 h dark schedule

In particular, those most investigated, the cobalt (II) salts, were known to be toxic to the heart, liver, and kidney (Speijers et al., 1982)

Low pH can cause corrosion in pipes, while high pH can cause scale buildup that shortens the lifespan of appliances