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Extended in vitro expansion and genetic modification of MSCs carry inherent risks of genomic instability, including chromosomal abnormalities and acquired mutations, which may compromise clinical safety

It is characterized by chronic dysfunction of the RPE, accumulation of drusen beneath the RPE, and progressive atrophy of the underlying choriocapillaris, which provides oxygen and nutrients to photoreceptor cells

doi: 10.3390/ijms22031357 91 KoevoetsI

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