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[DOI] [PMC free article] [PubMed] [Google Scholar] 45.Stromsdorfer KL, Yamaguchi S, Yoon MJ, Moseley AC, Franczyk MP, Kelly SC, Qi N, Imai S, Yoshino J

By inhibiting NNMT, the body maintains higher NAD levels, which in turn activate SIRT1, a longevity-associated gene, which may improve mitochondrial activity, fat oxidation, insulin sensitivity, and by overall energy balance

Researchers should approach dosing with appropriate caution and ideally work with knowledgeable healthcare providers

IGF-1 elevation from full HGH use is associated with increased cell proliferation risk, fluid retention, and carpal tunnel syndrome at therapeutic doses