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Decreases in TNF- and IL-1 were found in all studies measuring these parameters

Martini S

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Fontana, L., Ghezzi, L., Cross, A

These two factors (nail plate thickness variation and changes in keratinocytes along the nail plate) might play a role in the color disposition found in argyric nails (azure lunula), as well as a richer vascularization toward the nail matrix when compared to the nail midbed [148]