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The animal literature is unusually consistent, though: nearly every published in vivo study used 5 mg/kg per injection, given three times on alternate days (days 1, 3, and 5, or days 14, 16, and 18 in the pulmonary fibrosis model), with effects tracked over the following three to four weeks

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This strategy combines the biological effects of PBM with medical devices, aiming to promote post-operative repair, reduce inflammatory responses, and inhibit KOA progression ( 4 Discussion 4.1 Potential advantages of intra-articular PBM for KOA The proposal of intra-articular PBM represents not merely a circumvention of the limitations of percutaneous PBM techniques, but an innovation in therapeutic philosophy