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Such discouraging findings have prompted research efforts directed at the development of small molecules configured to penetrate the blood-brain-barrier (BBB) and stimulate brain neurotrophins

doi: 10.1007/s10787-017-0330-7

This systemic distribution makes Tb-500 particularly valuable when dealing with multiple injury sites or when whole-body recovery support is desired

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Laboratory studies have demonstrated biological activity at concentrations as low as 0.01 nanomolar, showing measurable effects on fibroblast activity and collagen production even at these minute levels