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Endothelial dysfunction is characterized by impaired vascular tone and homeostasis, often indicated by reduced NO production, increased oxidative stress, and elevated inflammatory responses [15]

Die Ursachen der Alzheimer-Krankheit sind zum Teil im oxidativen Stress zu suchen

These compounds exhibit synergistic multi-component, multi-target, multi-pathway effects, exemplified by berberine improving renal fibrosis markers (MMP2, TGF-1) through iron metabolism and oxidative stress regulation (Wang et al., 2023)

I.RamenskaiaG

Meanwhile, Gene Set Enrichment Analysis (GSEA) 36,37 indicates the down-regulated DEGs associated with synapse, including pre- and postsynaptic membrane, dendrite development, axonogenesis, actin and filament binding, etc