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These alterations in synaptic activity provide insights into the regional vulnerabilities contributing to NPS in AD

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DNA hairpin for magnetic tweezers experiments The design of a DNA hairpin substrate consisting of a 1238 bp hairpin with a 4 nt loop (4 dTs), a 74 bp dsDNA fragment ligated to a 126 bp highly biotinylated dsDNA handle, and a 146 bp 3-digoxigenin labelled dsDNA tail was based on a previous published construct with some modifications 79

When these barriers are compromised, inflammatory signals can spread more easily through the body and into the brain

While certain NF-B-regulated genes play a major role in regulating the amount of ROS in the cell, ROS have various inhibitory or stimulatory roles in NF-B signaling