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This results in decreased autophagy and increased apoptosis, contributing to Schwann cell dysfunction

Additionally, the study aimed to explore the methyl-dependent epigenetic mechanisms that play a role in regulating these biomarkers as well as investigate the potential of vitamin B12 in modulating the gene expression of these genes in leukocytes

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The effects of the Tbx1 mutation on brain metabolism were analysed first by reporting the results obtained in PBS-treated Tbx1 +/ and WT brains, followed by those obtained in vB12-treated animals with the same genotypes