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Having demonstrated that GLP-1MK-801 and GLP-1inactive MK-801 display comparable pharmacokinetic properties in vitro, we next assessed their respective in vivo efficacies against the parent GLP-1 analogue in DIO mice

1B and representative histograms in Fig

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Postmortem studies show elevated GSK3 activity in individuals with MDD and bipolar disorder, and animal models demonstrate that GSK3 inhibition in the nucleus accumbens produces antidepressant effects (150, 151)

896 Eldecalcitol (ED-71), a novel active vitamin D, also attenuates hyperglycemia-induced HIF1- overexpression and prevents osteoblast ferroptosis