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Simultaneously, oxaliplatin significantly increases superoxide anion production, followed by high levels of intracellular ROS that may in turn lead to enzyme, lipid and protein damage, which leads to structural changes in peripheral nerves [23, 24]

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359 In both chronic hypoxia and Sugen/hypoxia-induced pulmonary hypertension rat models, BM-MSCs decreased pulmonary arterial pressure, ameliorated collagen deposition, and reduced thickening and muscularization

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