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Vitamin B12 Why it matters: Found naturally in animal foods, vitamin B12 regulates key metabolic processes in the body both directly and as a cofactor (or "helper molecule") for two enzymes (methionine synthase and L-methylmalonyl-coenzyme A mutase)

The obesity trial ran 46 weeks with roughly 60% completion, and the MASH trial ran 48 weeks

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Results FoB and MZB exhibit distinct glutathione-based redox dependencies To dissect the redox state of MZB and FoB in relation to the main antioxidant GSH, we studied the expression of Gclc , which is necessary for GSH synthesis 24 , in isolated MZB and FoB from spleens of C57BL/6J (B6 or wild-type) mice

Pros Can be very sensitive due to filling if complexity is low Can be very robust Can work quickly Cons Has poor performance compared to other systems such as quadrupoles Can have low sensitivity if you are looking at low abundance ions in a background of high abundance ions these will limit the fill of the trap before selection Ion fragmentation Collision cell Overview This technology is well established and the most common method of fragmentation