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Finally, emphasis was given to the possible integration of the nanoparticles with other emerging technologies for the symptomatic management of PD

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This degeneration of dopaminergic neurons is strongly linked to the generation of reactive oxygen species and oxidative stress as well as mitochondrial dysfunction, neuroinflammation, and aging (Dias et al., 2013)

Figure 1 2.1 Regulation of the GPX 4 regulatory pathway Cells are affected by multiple signal-regulating channels, such as apoptosis, necrotic and ferrotic channels

8.1.3 Selenium nanoparticles Se-NPs have been used as an antioxidant for various therapeutic purposes