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Large conductance voltage- and calcium-dependent K+ channel, a distinct member of voltage-dependent ion channels with seven N-terminal transmembrane segments (SO-S6), an extracellular N terminus, and an intracellular (S9-S10) C terminus

The 5 non-coding region of HMOX1 includes regulatory sequences such as the heme response element, metal response element, hypoxia response element, heat shock response element, antioxidant response element, as well as binding sites for activator protein-1 and specificity protein-1

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